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What is Avanafil?
Avanafil is a recently approved PDE5 inhibitor for erectile dysfunction treatment.
The drug works similarly to other PDE5 inhibitors but is maarked by much faster onset of action due to its quick absorption with maximum concentration in blood within 30 minutes.
The drug comes in tablets for oral administration in various strengths.
The inactive ingredients that enter into the composition of the drug are mannitol, hydroxylpropylcellulose, fumaric acid, low substituted hydroxypropylcellulose, magnesium stearate, calcium carbonate and ferric oxide.
When is Avanafil indicated?
Avanafil is indicated to treat erectile dysfunction associated with various causes, including medical problems and psychological ones.
The drug has proven to be effective in men with diabetes.
However, it will not work without sexual stimulation, during which chemicals that cause erection are released. It only keeps those chemicals in the pennies longer, allowing men to have and maintain a better erection.
How to take Avanafil ?
Avanafil is taken by mouth, 30 minutes prior to the sexual intercourse, regardless to meals. However, some patients report having engaged in sexual relation in as early as 15 minutes after the drug intake.
The usual starting dose is 100 mg, which can be up-titrated to a maximum daily dose of 200 mg or down-titrated to 50 mg according to individual tolerability and efficacy.
It is advised to use the lowest dose that works for you. Patients who concomitantly receive alpha-blockers should be initiated at 50 mg dose. The drug is administered when needed, with the maximum dosing frequency once per day.
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What are Avanafil side effects?
Avanafil most commonly reported side effects are headache, flushing, nasal blockage, nasopharyngitis and back pain. These side effects are usually transient and require not treatment. However, immediately report to your healthcare provider if you develop vision or hearing impairment, nausea, dizziness, priapism, chest pain or any signs of allergic reaction.
When is Avanafil contraindicated?
Avanafil is contraindicated for use in patients who concomitantly receive organic nitrates as well as patients with known allergic reactions to any of the drug components. It shouldn’t be used together with other PDE5 inhibitors for ED treatment. The drug is not approved for use in children and women.