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What is Tadalafil?
Tadalafil is a chemical substance that belongs to the family of selective enzyme inhibitors. The drug blocks the PDE5 enzyme which is responsible for eliminating the substance called cyclic guanosine monophosphate (cGMP).
cGMP regulates the size of blood vessels in the genital area, allowing for sustained erection, while PDE5 is normally the substance that decreases the amount of cGMP.
By inhibiting the PDE5 enzyme, tadalafil provides easier blood flow in the penis and prolongs the erection.
What are the indications for using Tadalafil?
Tadalafil is prescribed for patients with erectile dysfunction who wish to achieve a better or more prolonged state of erection. The drug is also used to treat benign prostatic hyperplasia (prostate enlargement).
Tadalafil is extremely beneficial for patients with symptoms of both conditions, as well. Another indication of tadalafil use is pulmonary arterial hypertension.
What is the dosage of Tadalafil?
The typical dosages of the active ingredient in tadalafil tablets available today range from 10 mg to 40 mg. For erectile dysfunction treatment, 20 mg per day once prior to planned sexual activity is the normal dose.
Sometimes a course of tadalafil will be prescribed when a 10 mg tablet is taken daily, without regard for sexual activity.
The dosage may be upped to 20 mg per day if the effect is not sufficient. This dosage of tadalafil is also used to treat prostatic hyperplasia.
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For pulmonary arterial hypertension treatment, the recommended tadalafil dose is 40 mg per day (two 20 mg tablets taken once).
What are the contraindications for using Tadalafil?
You should not use tadalafil if you are using nitrate-containing drugs or other products. Nitrates widen the blood vessels, which together with tadalafil’s enzyme inhibiting action may lead to severe hypotension (low blood pressure). Specific sensitivity to tadalafil should also be taken into consideration before the drug use.
What are the adverse effects of Tadalafil?
Some of the most reported side effects of tadalafil treatment include headache (around 10% of cases), indigestion, muscle pain, hypotension, and prolonged erection (less than 10% of cases). A personal consultation with your doctor might be required to gauge the extent of possible complications of tadalafil use considering your personal medical record.